PhD studentship bridging causal inference and pharmacometrics

Summary

Co-supervised by Novartis Pharmacometrics Department and Uppsala University in Sweden, the INVENTS project consortium aims to develop methods, workflows, and evidence-tools to enhance the development and evaluation of evidence in rare diseases and pediatric populations. This initiative recognizes the critical role of pharmacometrics models in drug development, particularly when addressing the complexities of dose response relationships and causal interpretations in small sample size populations.

About the Role

Major Accountabilities:

• Assess types of intercurrent events impacting the interpretation of efficacy or safety endpoint measurements in the target population.
• Contrast strategies with the necessary assumptions to manage such intercurrent events.
• Develop causal inference methodologies tailored to pharmacometrics models to identify valid estimators yielding unbiased estimates.
• Create model diagnostics tools to evaluate whether a model supports causal interpretation.
• Conduct simulation studies and analyze real clinical data to assess the impact and limitations of proposed methodologies on evidence generated.

Minimum Requirements

• Master's degree or equivalent in fields such as statistics, pharmacometrics, mathematics, engineering, biomedicine, or medicine, with a strong interest in causal inference.
• Enthusiasm for integrating causal inference principles with pharmacometrics.
• Strong interpersonal and communication skills.
• Experience in scientific computing and programming.

Desirable Requirements

• Expertise or coursework in causal inference.
• Proficiency in R programming.
• Familiarity with modeling & simulation software such as NONMEM or Monolix Suite.

Languages

• Fluency in English, with an IELTS (academic) total score of 6.5 or higher, or equivalent.

Why Novartis

At Novartis, our purpose is to reimagine medicine to improve and extend people's lives. Our vision is to be the most valued and trusted medicines company globally. Achieving this vision relies on our people, driving us towards our ambitions. We invite you to be a part of this mission and join us!

Accessibility and Accommodation

Novartis is dedicated to providing reasonable accommodation for all individuals. If you have a medical condition or disability and require assistance during the recruitment process, please reach out to us to discuss your needs.

Benefits and Rewards

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