Two PhD positions in Biophysics and rheology of bacterial biofilms

Join Our Interdisciplinary Research Team

The bioMatter Microfluidics Group at ETH Zurich, under the guidance of Dr. Eleonora Secchi, is inviting talented individuals to engage in pioneering research focusing on the physicochemical mechanisms of microbial surface colonization and biofilm dynamics. Our team, composed of approximately 10 members, thrives in an international and collaborative environment within the Institute of Environmental Engineering.

Research Background

We are embarking on an exciting project funded by the SNSF, aimed at exploring the nonlinear rheology of biofilms, specifically examining the influence of extracellular DNA (eDNA). Biofilms, a prevalent form of microbial life, play critical roles in various sectors, including medicine and industry, and carry significant implications due to their contribution to persistent infections and antibiotic resistance.

Key Responsibilities

• Conduct experimental investigations into nonlinear rheology and stress-hardening behaviors of bacterial biofilms with diverse morphologies using specialized microfluidic and rheometry tools.
• Assess the role of eDNA in biofilm dynamics through the use of mutant libraries, assays, and controlled physicochemical environments; explore the effects of exogenous DNA on biofilm characteristics.
• Implement advanced fluorescence and confocal imaging techniques to analyze biofilm structure and eDNA configurations in situ.
• Advance the development of numerical models to predict biofilm mechanical behaviors.
• Collaborate with a diverse team and external partners to communicate findings through publications and presentations.

The role encompasses wet-lab experimentation, project management, numerical modeling, and teaching responsibilities.

Position Details

Successful candidates can expect a fully funded PhD opportunity lasting approximately four years, commencing on February 1, 2026, or by mutual agreement. Continuation in the doctoral programme is contingent upon a successful Aptitude Colloquium at the end of the first year.

Candidate Profile

The ideal candidates hold a Master’s degree in:

• Physics, biophysics, materials science, microbiology, or a related field, displaying a strong interest in interdisciplinary research linking soft-matter physics and microbiology.
• Prior experience in experimental methodologies, including microfluidics, rheology, microscopy, or microbial culture, along with proficiency in data analysis and quantitative modeling, is highly regarded.
• A motivation to work independently as well as collaboratively within an international research setting is crucial, alongside an eagerness to contribute to teaching activities.

Work Environment

Our team offers various professional development opportunities, career advancement prospects, and supportive programs that foster an inclusive and diverse workplace. We are committed to maintaining a flexible environment that promotes a work-life balance, including options for part-time work and remote arrangements.

Our Commitment to Diversity and Sustainability

ETH Zurich champions an inclusive culture that promotes equality and values diversity, nurturing a working environment that respects the rights and dignity of all staff and students. Sustainability is central to our values as we actively pursue a climate-neutral future.

Explore the Opportunities

We look forward to welcoming passionate individuals who are eager to contribute to groundbreaking research and expand their academic horizons in a dynamic environment. Join us in addressing global challenges through innovative science and technology.