Senior Principal Scientist - siRNA Chemistry

Position Overview

Located in Basel, Switzerland, this role involves full-time, onsite collaboration within the Novartis BioMedical Research division, which serves as the innovation engine for therapeutic breakthroughs. Join a team dedicated to improving and extending lives through innovative science and technology, focusing on addressing complex healthcare challenges.

Core Responsibilities

The successful candidate will:

• Engage collaboratively in a multidisciplinary project team to develop novel oligonucleotide therapies targeting various disease areas.
• Lead a team in the design and synthesis of new nucleotide building blocks, linkers, and backbones from small to medium scale.
• Intellectually contribute to project success by exploring innovative siRNA chemistries and ensuring smooth transition to development.
• Direct siRNA drug discovery projects in partnership with leaders from other functions.
• Critically analyze project data using advanced data analysis tools to tackle complex challenges, developing hypotheses and designing molecules.
• Drive innovation by developing new projects and solutions in RNA therapeutics through collaboration with internal and external partners globally.
• Document and communicate scientific findings effectively to diverse audiences, including in patent filings and publications.
• Mentor and support team members through knowledge sharing and hands-on experience.

Required Qualifications

Ideal candidates will possess:

• A PhD in a relevant field focusing on oligonucleotide synthesis and design.
• A minimum of 8 years of practical experience in medicinal chemistry specifically with oligonucleotides, with a proven track record of successful deliverables.
• Strong leadership skills with demonstrated success in developing people.
• A curious mindset, open to diverse thinking, eager to grow personally and professionally.
• Innovative and independent problem-solving capabilities.
• An interest in disruptive technologies, data science, and automation as they relate to drug discovery.
• Excellent communication and influencing skills, adept at discussing strategies and challenges with varied stakeholders.

Company Commitment

The organization is dedicated to fostering a diverse and inclusive environment, acknowledging the value of varied perspectives that represent the patients and communities served. Novartis is also committed to ensuring accessibility and providing reasonable accommodations as needed.

Join the Novartis Community

Be part of a community that drives ambition and innovative breakthroughs in the medical field. Collaborate, support, and inspire one another to make a significant impact on patients' lives. Explore more about the company’s mission, benefits, and community initiatives to see how you can contribute and thrive.