Research Scientist: RNAi Formulations

Be the Heartbeat of Medical Research

Join our client to assist in turning innovative science into life-changing care. This role focuses on hands-on RNAi formulation development, biophysical and analytical characterization, and supporting oligonucleotide delivery activities for injectable therapeutics.

Primary Responsibilities

• Support the development and characterization of preclinical RNAi and oligonucleotide formulations across portfolio and platform projects.
• Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
• Establish and run screening assays for oligonucleotides in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, and stability assessments.
• Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
• Support long-term storage and stability evaluations for RNAi conjugates and oligonucleotide formulations.
• Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
• Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
• Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
• Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.

Skills and Requirements

• MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or a related discipline.
• Hands-on experience with oligonucleotide or antibodies/proteins formulation and characterization is strongly preferred.
• Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, stability, or other developability assessments for complex oligonucleotide or antibody/protein formulations.
• Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
• Strong experimental planning, documentation, data analysis, and problem-solving skills.
• Excellent verbal and written communication skills, with the ability to work effectively across disciplines and functions.
• Awareness of external trends and advances in RNA delivery, oligonucleotide therapeutics, and clinical translation is a plus.
• A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.

Compensation

$35 to $39 per hour.