Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics

Summary

Located in Basel, Switzerland, this role offers an exciting opportunity to contribute to the development of xRNA therapeutics. We are looking for a passionate and experienced PhD-level scientist to lead the synthesis of mid to large-scale oligonucleotides and manage a dedicated team, enhancing our innovative siRNA therapies aimed at addressing significant medical needs.

About the Role

The principal responsibilities of this position encompass a variety of tasks, including:

• Planning and executing the synthesis, purification, and analysis of chemically modified oligonucleotides and conjugates.
• Overseeing a state-of-the-art oligonucleotide synthesis facility, with effective management of budgets.
• Leading and mentoring a team of scientists in oligonucleotide synthesis, purification, analysis, and downstream processing.
• Ensuring timely delivery of quality siRNA materials for in vitro screening and in vivo studies.
• Collaborating with discovery teams in Basel and Cambridge on oligonucleotide synthesis.
• Providing technical leadership to optimize methodologies for enhanced synthesis efficiency.
• Partnering with synthetic chemists to scale-up new siRNA chemistries.
• Documenting and communicating scientific findings to stakeholders through publications and patent applications.
• Mentoring and supporting team members with technical expertise and hands-on guidance.
• Demonstrating strong problem-solving skills and a solution-oriented approach.

Minimum Requirements

The ideal candidate will possess:

• A Ph.D. in Chemistry focusing on oligonucleotide synthesis, with 2-3 years of relevant industry experience.
• A proven track record in mid to large-scale solid-phase synthesis and downstream processing.
• Demonstrated leadership capabilities with experience in team development.
• The ability to foster and implement innovative ideas within a global team.
• Strong independent problem-solving skills and a collaborative mindset.
• Effective management of multiple priorities while staying focused on key objectives.
• Excellent verbal and written communication skills.

Why Join Us

At Novartis, we take pride in our commitment to creating a collaborative and inspiring work environment. Our mission extends beyond innovative science to encompass a community of passionate individuals ready to drive breakthroughs that change patients’ lives.

Benefits and Rewards

Explore the numerous benefits and opportunities for professional growth that we offer our team members, designed to help you thrive both personally and professionally.