Principal Scientist, Assay Profiling - Lead Identification and Optimization (80-100%*)

Summary

We are seeking a highly motivated, detail-oriented, and experienced biology expert to join our Lead Identification and Optimization (LIDO) team at our research site in Basel, Switzerland. As part of our LIDO team, you will accelerate drug discovery by producing high-quality data on compounds tested in cellular and biochemical profiling assays. You will work closely with colleagues in global Discovery Sciences (DSc) and drug discovery project teams within Biomedical Research (BR) located in Cambridge, San Diego, and Basel.

About the Role

You are a self-motivated, curious, creative, and agile biologist and leader with strong experience in developing cellular and/or biochemical profiling assays to support the early drug discovery process. You will contribute to lab work and process improvement while guiding and developing associates in our LIDO team. This role features a collaborative and fast-paced environment where your efforts will positively impact drug discovery by advancing early hits into drug development candidates.

Key Responsibilities

• Adapt biochemical and/or cellular profiling assays into robust and standardized formats to support the testing of newly synthesized compounds generated by project teams, focusing on fast turnaround times for data delivery.
• Manage LIDO associates.
• Develop, document, and maintain Standard Operating Procedures (SOPs) for LIDO processes and quality control.
• Proactively identify and implement improvements to enhance lab processes, performance, and reliability.
• Coordinate and plan the execution of LIDO profiling assays with internal stakeholders.
• Present LIDO management activities in cross-functional meetings.

Essential Requirements

• PhD in Biology, Biochemistry, or equivalent qualifications with 5+ years of relevant experience, or BSc or MSc in a related field with 10+ years of relevant experience.
• Proven experience in executing profiling assays in a low molecular weight (LMW) drug discovery organization.
• Strong expertise in either biochemical and/or cellular assay development in a drug discovery setting.
• High attention to detail and commitment to operational excellence.
• Strong organizational and time-management skills.
• Ability to work independently and collaboratively within multidisciplinary global teams.
• Flexibility and responsiveness to shifting priorities.
• Excellent written, verbal, and interpersonal English communication skills.

Why Join Us

At Novartis, helping people with disease and their families takes more than innovative science; it takes a community of smart, passionate individuals like you. Collaborating, supporting, and inspiring each other to achieve breakthroughs that change patients' lives is at the heart of our mission.

Benefits and Rewards

Discover the various ways we support your personal and professional growth.

We are dedicated to providing reasonable accommodation for all individuals. If you need assistance during the recruitment process due to a medical condition or disability, please reach out to discuss your needs.